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Model designed to replace invasive kidney biopsy for lupus patients

Mathematics might be able to reduce the need for invasive biopsies in patients suffering kidney damage related to the autoimmune disease lupus. In a new study, researchers developed a math model that can predict the progression from nephritis – kidney inflammation – to interstitial fibrosis, scarring in the kidney that current treatments cannot reverse. A kidney biopsy is the only existing way to reach a definitive diagnosis of the damage and its extent. The model could also be used to monitor the effectiveness of experimental treatments for inflammation and fibrosis.

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